SIC5-6
Modify Date: 2024-04-07 18:04:21
SIC5-6 structure
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Common Name | SIC5-6 | ||
|---|---|---|---|---|
| CAS Number | 2410846-16-9 | Molecular Weight | 581.47 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H24IN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SIC5-6SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1]. |
| Name | SIC5-6 |
|---|
| Description | SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1]. |
|---|---|
| Related Catalog | |
| Target |
Separase[1] |
| In Vitro | SIC5-6 (30 μM, 100 μM) 增加 HeLa 细胞中 Caspase-1 活性和 Rad21 裂解。(Rad21：含有与荧光染料 Rh110 (HY-D0817) 结合的 Separase 裂解位点)[1] |
| References |
| Molecular Formula | C27H24IN3O2S |
|---|---|
| Molecular Weight | 581.47 |
| InChIKey | JRVKJWXBSOQUOI-UHFFFAOYSA-N |
| SMILES | O=S(=O)(c1ccc(I)cc1)N1CCC(c2c[nH]c3ccccc23)(c2c[nH]c3ccccc23)CC1 |