2240164-55-8

2240164-55-8 structure

Name: Oleoyl-D-lysine
Chemical Name: Oleoyl-D-lysine
CAS Number: 2240164-55-8
Molecular Formula: C₂₄H₄₆N₂O₃
Molecular Weight: 410.63
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2023-05-23 23:52:01
Modify Date: 2024-01-10 16:19:34
Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression[1].

Name	Oleoyl-D-lysine

Description	Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	Glycine Transporter-2 (GlyT2)[1]
In Vivo	Oleoyl-D-lysine effectively reverses neuropathic pain in a mouse model of chronic neuropathic (chronic constriction injury) pain, reaching a peak analgesic dose of 30 mg/kg without causing respiratory depression; resultig mild side effects at 100 mg/kg without causing convulsions[1].
References	[1]. Wilson BS, et al. Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice. J Pharmacol Exp Ther. 2022 Sep;382(3):246-255.

Molecular Formula	C₂₄H₄₆N₂O₃
Molecular Weight	410.63