2414254-49-0

2414254-49-0 structure

Name: Gly-Cyclopropane-Exatecan
Chemical Name: Gly-Cyclopropane-Exatecan
CAS Number: 2414254-49-0
Molecular Formula: C₃₂H₃₄FN₅O₇
Molecular Weight: 619.64
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2023-04-24 10:05:47
Modify Date: 2024-04-06 18:11:19
Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].

Name	Gly-Cyclopropane-Exatecan

Description	Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan (HY-13631), a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Topoisomerase I
References	[1]. Hua Haiqing, et al. Anti-b7-h4 antibody-drug conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020244657. 2020-12-10.

Molecular Formula	C₃₂H₃₄FN₅O₇
Molecular Weight	619.64