1422527-87-4
1422527-87-4 structure
- Name: Antitumor agent-88
- Chemical Name: Antitumor agent-88
- CAS Number: 1422527-87-4
- Molecular Formula: C23H30N2O7S
- Molecular Weight: 478.56
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2023-04-05 12:14:46
- Modify Date: 2024-04-06 01:21:06
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Antitumor agent-88 exhibits potent antimitotic activity and arrests cell in the G2/M phase. Antitumor agent-88 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells. Antitumor agent-88 is also a competitive inhibitor of CYP1A1 (Ki: 1.4 μM)[1].
| Name | Antitumor agent-88 |
|---|
| Description | Antitumor agent-88 exhibits potent antimitotic activity and arrests cell in the G2/M phase. Antitumor agent-88 disrupts the microtubule and the cytoskeleton in CYP1A1-expressing breast cancer cells. Antitumor agent-88 is also a competitive inhibitor of CYP1A1 (Ki: 1.4 μM)[1]. |
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| Related Catalog | |
| Target |
CYP1A1:1.4 μM (Ki) |
| In Vitro | Antitumor agent-88 (Compound 14, 48 h) 抑制 MCF-7 细胞生长，IC50 为 200 nM，对 MDA-MB-231 (IC50 >8600 nM)[1]。 Antitumor agent-88 抑制 MDA-MB-468、SK-BR 细胞生长，IC50 分别为 21 nM、3.2 nM[1]。 Antitumor agent-88 (50 nM, 48 h) 导致 42% 细胞在 G2/M 期停滞[1]。 Antitumor agent-88 对 CYP1A1 具有高亲和力 (Ki: 1.4 μM)[1]。 Antitumor agent-88 选择性抑制 HT-1080 细胞增殖，对转染 CYP1A1 的 HT-1080 的 IC50 为 30 nM[1]。 Cell Viability Assay[1] Cell Line: MCF-7 cell Concentration: 50 nM Incubation Time: 48 h Result: Arrested cell in G2/M phase. |
| In Vivo | Antitumor agent-88 (化合物 14) (1 μg/蛋) 在携带 HT-1080CYP1A1 肿瘤的鸡胚中显示出抗肿瘤活性[1]。 Animal Model: Chick embryos grafted with HT-1080CYP1A1 cells[1] Dosage: 1 μg/egg Administration: Applied to chick chorioallantoic membrane. Result: Reduced tumor weight by 49%. |
| References |
| Molecular Formula | C23H30N2O7S |
|---|---|
| Molecular Weight | 478.56 |