25848-69-5

25848-69-5 structure

Name: 7β-Hydroxy-epi-androsterone
Chemical Name: 7β-Hydroxy-epi-androsterone
CAS Number: 25848-69-5
Molecular Formula: C₁₉H₃₀O₃
Molecular Weight: 306.44
Catalog: Research Areas Inflammation/Immunology
Create Date: 2023-04-11 18:03:31
Modify Date: 2024-04-06 11:17:20
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].

Name	7β-Hydroxy-epi-androsterone

Description	7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone[1][2][3].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	ERβ
In Vitro	7β-Hydroxy-epi-androsterone (1、10 和 100 nM，72 小时) 在 E2 (10 nM) 存在的情况下抑制 MCF-7 和 MDA-MB-231 细胞增殖[2]。 7β-Hydroxy-epi-androsterone (1、10 和 100 nM，48 小时) 导致 MCF-7 和 MDA-MB-231 细胞的 G0/G1 细胞周期停滞[2]。 7β-Hydroxy-epi-androsterone (1、10 和 100 nM，48 小时) 在 E2 (10 nM) 存在的情况下增加 MCF-7 细胞的细胞凋亡[2]。 7β-Hydroxy-epi-androsterone (1、10 和 100 nM，24 小时) 与 ERβ 结合并降低 MDA-MB-231 细胞中的反式激活[2]。 Apoptosis Analysis[2] Cell Line: MCF-7 cells Concentration: 1, 10 and 100 nM (in presence of 10 nM E2) Incubation Time: 48 h Result: Increased cell apoptosis in presence of E2.
In Vivo	7β-Hydroxy-epi-androsterone (i.p.，每天一次，连续 7 天) 对 DSS 诱导的结肠炎大鼠显示出抗炎作用[3]。 7β-Hydroxy-epi-androsterone (0.1 mg/kg 皮下注射，每日两次，持续 10 天) 对阿尔茨海默病大鼠的炎症性神经变性和神经胶质细胞死亡展现出保护作用[4]。 Animal Model: Rat with DSS-induced colitis[3] Dosage: 0.01, 0.1 and 1 mg/kg Administration: Intraperitoneal injection (i.p.), once a day for 7 days. Result: Increased in COX-2 and PGE synthase expression. Increased colonic tissue levels of 15d-PGJ2 levels.
References	[1]. Christophe Ricco, et al. Synthesis of 7β-hydroxy-epiandrosterone. Steroids. Volume 76, Issues 1-2, January 2011, Pages 28-30. [2]. Sandra N, et al. The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines. Steroids. 2012 Apr;77(5):542-51. [3]. Hennebert O, et al. Anti-inflammatory effects and changes in prostaglandin patterns induced by 7beta-hydroxy-epiandrosterone in rats with colitis. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):255-62. [4]. Dudas B, et al. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8.

Molecular Formula	C₁₉H₃₀O₃
Molecular Weight	306.44

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