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1627900-92-8

1627900-92-8 structure

1627900-92-8 structure

Name: P2X7 receptor antagonist-3
Chemical Name: P2X7 receptor antagonist-3
CAS Number: 1627900-92-8
Molecular Formula: C₁₇H₁₂ClF₃N₆O
Molecular Weight: 408.76
Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
Create Date: 2023-02-04 12:09:22
Modify Date: 2025-08-25 11:58:41
P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].

Name	P2X7 receptor antagonist-3

Description	P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor Research Areas >> Neurological Disease
Target	hP2X7R:4.2 nM (IC50) rP2X7R:6.8 nM (IC50)
References	[1]. Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6(6):671-6.

Molecular Formula	C₁₇H₁₂ClF₃N₆O
Molecular Weight	408.76

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