895460-70-5
895460-70-5 structure
- Name: BRD7586
- Chemical Name: 3-(4-chlorophenyl)sulfonyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)propanamide
- CAS Number: 895460-70-5
- Molecular Formula: C17H14ClN3O3S2
- Molecular Weight: 407.89436
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CRISPR/Cas9
- Create Date: 2023-01-19 17:57:04
- Modify Date: 2024-09-25 19:27:46
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BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9. BRD7586 is the smallest known anti-CRISPR[1].
| Name | 3-(4-chlorophenyl)sulfonyl-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)propanamide |
|---|
| Description | BRD7586 is a cell-permeable small-molecule inhibitor of SpCas9. BRD7586 is the smallest known anti-CRISPR[1]. |
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| Related Catalog | |
| In Vitro | BRD7586在细胞中特异性地与 SpCas9 结合，但不与 Cas12a 结合[1]。 BRD7586 (0-20 μM; 24 h) 在 HiBiT-knock-in 试验中，呈剂量依赖性地抑制 SpCas9[1]。 BRD7586 (20 μM; 48 h) 增强 HEK293T 细胞中中靶与脱靶的比值[1]。 |
| References |
| Molecular Formula | C17H14ClN3O3S2 |
|---|---|
| Molecular Weight | 407.89436 |