1565796-97-5

1565796-97-5 structure

Name: PBB3
Chemical Name: 6-Benzothiazolol, 2-[(1E,3E)-4-[6-(methylamino)-3-pyridinyl]-1,3-butadien-1-yl]-
CAS Number: 1565796-97-5
Molecular Formula: C₁₇H₁₅N₃OS
Molecular Weight: 309.39
Catalog: Research Areas Neurological Disease
Create Date: 2023-01-17 12:54:09
Modify Date: 2024-11-30 17:18:24
PBB3, a selective PET ligand, recognizes tau pathology in Alzheimer's disease brains, where dystrophic neurites and diffuse neurofibrils are more clearly detected Tangles with calcification[1].

Name	6-Benzothiazolol, 2-[(1E,3E)-4-[6-(methylamino)-3-pyridinyl]-1,3-butadien-1-yl]-
Synonyms	PBB-3 2-{(1E,3E)-4-[6-(Methylamino)-3-pyridinyl]-1,3-butadien-1-yl}-1,3-benzothiazol-6-ol 6-Benzothiazolol, 2-[(1E,3E)-4-[6-(methylamino)-3-pyridinyl]-1,3-butadien-1-yl]-

Description	PBB3, a selective PET ligand, recognizes tau pathology in Alzheimer's disease brains, where dystrophic neurites and diffuse neurofibrils are more clearly detected Tangles with calcification[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Maiko Ono, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain. 2017 Mar 1;140(3):764-780.