99141-91-0
99141-91-0 structure
- Name: ZZL-7
- Chemical Name: ZZL-7
- CAS Number: 99141-91-0
- Molecular Formula: C11H20N2O4
- Molecular Weight: 244.29
- Catalog: Signaling Pathways Neuronal Signaling Serotonin Transporter
- Create Date: 2023-01-11 11:10:46
- Modify Date: 2024-04-05 19:37:06
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ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD)[1].
| Name | ZZL-7 |
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| Description | ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD)[1]. |
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| Related Catalog | |
| In Vitro | ZZL-7 (1.0 μM; or 2 h) incubation of the cultured 293T cells transfected with nNOS and SERT, significantly decreases the SERT-nNOS complex level[1]. |
| In Vivo | ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1]. Intragastric administration of ZZL-7 (10, 20, and 40 mg/kg; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment[1]. ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment[1]. Animal Model: SERT-Cre mice[1] Dosage: 10 mg/kg Administration: i.p.; once Result: Significantly increased firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. |
| References |
| Molecular Formula | C11H20N2O4 |
|---|---|
| Molecular Weight | 244.29 |