1375752-77-4

1375752-77-4 structure

1375752-77-4 structure

Name: (S,S)-BMS-984923
Chemical Name: (S,S)-BMS-984923
CAS Number: 1375752-77-4
Molecular Formula: C₂₂H₁₅ClN₂O₂
Molecular Weight: 374.82
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2023-01-17 13:12:02
Modify Date: 2023-01-17 13:12:02
(S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor[1]. BMS-984923 is a potent mGluR5 silent allosteric modulator[2].

Name	(S,S)-BMS-984923

Description	(S,S)-BMS-984923 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor[1]. BMS-984923 is a potent mGluR5 silent allosteric modulator[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Andrew P. Degnan, et al. Oxazolidinones as modulators of mglur5. WO2012064603A1. [2]. Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.

Molecular Formula	C₂₂H₁₅ClN₂O₂
Molecular Weight	374.82