372495-52-8

372495-52-8 structure

Name: UNC10201652
Chemical Name: UNC10201652
CAS Number: 372495-52-8
Molecular Formula: C₂₀H₂₅N₇OS
Molecular Weight: 411.52
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-10-23 09:36:49
Modify Date: 2024-04-03 08:10:37
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2].

Name	UNC10201652

Description	UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.117 μM (E. coli GUS)[1] EC50: 74±7 nM (E. coli)[1]
In Vitro	UNC10201652 exhibits potently inhibitory activity against wild type E. coli with an EC50 of 74±7 nM[2].
References	[1]. Jariwala PB, et al. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS Chem Biol. 2020 Jan 17;15(1):217-225. [2]. Pellock SJ, et al. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci. 2018 Jul 25;4(7):868-879.

Molecular Formula	C₂₀H₂₅N₇OS
Molecular Weight	411.52