2512847-37-7
2512847-37-7 structure
- Name: SAP2-IN-1
- Chemical Name: SAP2-IN-1
- CAS Number: 2512847-37-7
- Molecular Formula: C34H29NO7
- Molecular Weight: 563.60
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2022-10-24 10:05:30
- Modify Date: 2025-08-26 20:17:28
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SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection[1].
| Name | SAP2-IN-1 |
|---|
| Description | SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection[1]. |
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| Related Catalog | |
| Target |
IC50: 0.92 μM (SAP2)[1] |
| In Vitro | SAP2-IN-1 (compound 24a) (100 μM) shows potent SAP2 inhibitory activity with an IC50 value of 0.92 μM[1]. SAP2-IN-1 (100 μM) has not inhibit the growth of C. albicans and inactive in vitro[1]. SAP2-IN-1 (64 μg/mL) blocks fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1[1]. RT-PCR[1] Cell Line: C. albicans cells Concentration: 64 μg/mL Incubation Time: Result: Inhibited hypha growth through the cAMP-dependent pathway. |
| In Vivo | SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis[1]. Animal Model: a murine model of invasive candidiasis[1] Dosage: 10 mg/kg Administration: intraperitoneally administration, once daily, for four days Result: Significantly reduced the fungal burden in the kidney. |
| References |
| Molecular Formula | C34H29NO7 |
|---|---|
| Molecular Weight | 563.60 |