865317-32-4
865317-32-4 structure
- Name: CP681301
- Chemical Name: CP681301
- CAS Number: 865317-32-4
- Molecular Formula: C17H22N4O
- Molecular Weight: 298.38
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-11-21 17:28:59
- Modify Date: 2024-01-20 11:19:13
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CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila[1].
| Name | CP681301 |
|---|
| Description | CP681301 is a potent CDK5 inhibitor. CP681301 shows antiproliferative activity. CP681301 decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs (Glioma stem cells). CP681301 reduces self-renewal in mouse glioma xenografts. CP681301 shows anti-tumor activity in Drosophila[1]. |
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| Related Catalog | |
| In Vitro | CP681301 (1 µM; 96 h) shows variably cytotoxic to the tested GSC cultures but is not toxic to NHNPs[1]. CP681301 (0, 10, 50 µM; 48 h) decreases the expression of CD133, OLIG2, SOX2, KI67, pCDK5 protein level in GSCs[1]. CP681301 (0, 0.5, 1 µM; ) suppresses the expression of CREB Ser133 phosphorylation[1]. Cell Cytotoxicity Assay[1] Cell Line: NHNP, N12.159, GBM121, GBM39, N08-74 cells Concentration: 1 µM Incubation Time: 96 h Result: Showed variably cytotoxic to the tested GSC cultures but was not toxic to NHNPs (normal human neuro-progenitors). Western Blot Analysis[1] Cell Line: GBM 121, GBM39 cells Concentration: 1 µM Incubation Time: 48 h Result: Suppressed the expression of CD133, OLIG2, and SOX2 and cell proliferation marker KI67. |
| In Vivo | CP681301 (1 mM; fed; 10 days) shows anti-tumor activity in 0- to 2-day-old adult Drosophila[1]. Animal Model: 0- to 2-day-old adult Drosophila (brat-RNAi tumors)[1] Dosage: 1 mM Administration: Fed, 10 days Result: Reduced active phospho-dCdk5 (Y15) in tumor cells and the self-renewal properties of stem cells, increased the expression of neuronal marker ElaV in these cells and increased the median survival by 2.8-fold. |
| References |
| Molecular Formula | C17H22N4O |
|---|---|
| Molecular Weight | 298.38 |