2738381-52-5
2738381-52-5 structure
- Name: Anti-infective agent 4
- Chemical Name: Anti-infective agent 4
- CAS Number: 2738381-52-5
- Molecular Formula: C19H12F3N5O4
- Molecular Weight: 431.32
- Catalog: Research Areas Infection
- Create Date: 2022-10-23 17:08:25
- Modify Date: 2024-04-02 21:08:06
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Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection[1].
| Name | Anti-infective agent 4 |
|---|
| Description | Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection[1]. |
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| Related Catalog | |
| Target |
IC50: 0.016 μM (Trypanosoma cruzi)[1] |
| In Vitro | Anti-infective agent 4 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.016 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: 3T3 cells Concentration: 0.1 nM-100 μM Incubation Time: 48 hours Result: Showed activity against 3T3 cells with an CC50 value of ＞37 μM. |
| In Vivo | Anti-infective agent 4 (50 mg/kg; p.o. once daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1]. Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg once daily for five days Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice. |
| References |
| Molecular Formula | C19H12F3N5O4 |
|---|---|
| Molecular Weight | 431.32 |