2642382-41-8

2642382-41-8 structure

Name: Ultevursen
Chemical Name: Ultevursen
CAS Number: 2642382-41-8
Molecular Formula: C₂₇₃H₃₉₁N₈₁O₁₄₄P₂₀S₂₀
Molecular Weight: 8372.24
Catalog: Research Areas Others
Create Date: 2022-09-17 18:40:46
Modify Date: 2024-09-21 17:35:23
Ultevursen (QR-421a) is a single-stranded RNA based oligonucleotide that is designed to skip exon 13 in the RNA with the aim to stop vision loss in people that have retinitis pigmentosa due to a mutation in exon 13 of the USH2A gene (encoding usherin). Ultevursen sequence: (P-thio)[2′-O-(2-methoxyethyl)](A-G-m5C-m5U-m5U-m5C-G-G-A-G-A-A-A-m5U-m5U-m5U-A-A-A-m5U-m5C) (ACI)[1].

Name	Ultevursen

Description	Ultevursen (QR-421a) is a single-stranded RNA based oligonucleotide that is designed to skip exon 13 in the RNA with the aim to stop vision loss in people that have retinitis pigmentosa due to a mutation in exon 13 of the USH2A gene (encoding usherin). Ultevursen sequence: (P-thio)[2′-O-(2-methoxyethyl)](A-G-m5C-m5U-m5U-m5C-G-G-A-G-A-A-A-m5U-m5U-m5U-A-A-A-m5U-m5C) (ACI)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Usherin[1]
References	[1]. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.

Molecular Formula	C₂₇₃H₃₉₁N₈₁O₁₄₄P₂₀S₂₀
Molecular Weight	8372.24