1459695-66-9

1459695-66-9 structure

Name: TXA6101
Chemical Name: TXA6101
CAS Number: 1459695-66-9
Molecular Formula: C₁₈H₁₀BrF₅N₂O₃
Molecular Weight: 477.18
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-09-10 21:48:05
Modify Date: 2025-08-25 14:00:41
TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2].

Name	TXA6101

Description	TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	TXA6101 has antibacterial activity against MRSA with the MIC value of 0.125 μg/mL while TXA707 with the MIC value of 1 μg/mL[2]. TXY6129 inhibits the polymerization of Escherichia coli FtsZ in a concentration-dependent manner and induces morphological changes in Escherichia coli and Klebsiella pneumoniae[3].
References	[1]. Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel). 2020 Feb 7;9(2):69. [2]. Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12(7):1947-1955. [3]. Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3-(oxazol-2-ylmethoxy)benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo). 2022 Jul;75(7):385-395.

Molecular Formula	C₁₈H₁₀BrF₅N₂O₃
Molecular Weight	477.18