2765793-54-0

2765793-54-0 structure

Name: Phytoene desaturase-IN-1
Chemical Name: Phytoene desaturase-IN-1
CAS Number: 2765793-54-0
Molecular Formula: C₁₈H₁₃ClF₃N₃O₂S
Molecular Weight: 427.83
Catalog: Research Areas Others
Create Date: 2022-09-10 15:21:31
Modify Date: 2025-08-25 10:03:30
Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (Kd: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production[1].

Name	Phytoene desaturase-IN-1

Description	Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (Kd: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	Phytoene desaturase (PDS), reactive oxygen species (ROS)[1].
In Vitro	Phytoene desaturase-IN-1 (1b, 375−750 g/ha, 25 days) shows a broad spectrum of herbicidal activity against six kinds of weeds (including ECHCG, DIGSA, SETFA, ABUJU, AMARE, and ECLPR)[1]. Phytoene desaturase-IN-1 (750 g/ha, 14 days) down-regulates PDS mRNA level and induces phytoene accumulation, with the observed albino leaf phenotype[1]. Phytoene desaturase-IN-1 (750 g/ha, 3 days) induces ROS accumulation and regulates ROS-associated enzymes activity[1]. RT-PCR[1] Cell Line: Albino leaves Concentration: 750 g/ha Incubation Time: 14 days Result: Reduced PDS mRNA level by 30%, thereby limiting the catalytic dehydrogenation process of phytoene and causing phytoene accumulation.
References	[1]. Di Zhang, et al. Discovery of (5-(Benzylthio)-4-(3-(trifluoromethyl)phenyl)-4 H-1,2,4-triazol-3-yl) Methanols as Potent Phytoene Desaturase Inhibitors through Virtual Screening and Structure Optimization. J Agric Food Chem. 2022 Aug 10.

Molecular Formula	C₁₈H₁₃ClF₃N₃O₂S
Molecular Weight	427.83

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