2414633-49-9

2414633-49-9 structure

Name: CDK1/2/4-IN-1
Chemical Name: CDK1/2/4-IN-1
CAS Number: 2414633-49-9
Molecular Formula: C₁₅H₁₆N₂O₂S
Molecular Weight: 288.36
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-09-05 22:30:17
Modify Date: 2025-08-27 17:53:30
CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].

Name	CDK1/2/4-IN-1

Description	CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK1:1.47 (IC50) CDK2:0.78 (IC50) CDK4:0.87 (IC50) Caspase 3 Bax Bcl-2
In Vitro	CDK1/2/4-IN-1 (compound 3a) (0.01-100 µM; 24 hours) has antitumor activity in cancer cell lines[1]. CDK1/2/4-IN-1 (compound 3a) (1.39 µM; 24 hours) induces apoptosis and arrests cell cycle at G2/M phase in A549 cells[1]. CDK1/2/4-IN-1 (compound 3a) (1.39 µM; A549 cells) induces up-regulation of the expression of Bax, caspases-3 and p53, and increases the ratio of Bcl-2[1]. Cell Cytotoxicity Assay[1] Cell Line: Liver cancer cell line (HepG-2), lung cancer cell line (A549) and breast cancer cell line (MCF-7) Concentration: 0.01, 0.1, 1.0, 10, 100 µM Incubation Time: 24 hours Result: Displayed cytotoxic activity with IC50 values of 1.56, 1.39 and 1.97 µM for HepG-2, A549 and MCF-7, respectively. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 1.39 µM Incubation Time: 24 hours Result: Increased G2/M phase by 2.6 folds compared with the control cells. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 1.39 µM Incubation Time: 24 hours Result: Increased the overall percentage of the apoptotic cells.
References	[1]. Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761.

Molecular Formula	C₁₅H₁₆N₂O₂S
Molecular Weight	288.36

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2414633-49-9	28879-19-8
111339-35-6	102705-79-3
61285-38-9	61285-43-6
76784-69-5	71000-11-8
250358-84-0	55402-12-5
2304636-61-9	1696379-92-6
2248389-46-8	2248313-67-7
2248175-04-2	2248364-50-1
2248318-37-6	1804712-10-4
1428940-42-4	2104368-15-0