2089159-00-0

2089159-00-0 structure

Name: PPARγ/δ modulator 1
Chemical Name: PPARγ/δ modulator 1
CAS Number: 2089159-00-0
Molecular Formula: C₁₈H₁₈ClIN₆O₃Se
Molecular Weight: 607.69
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2022-08-04 16:44:21
Modify Date: 2024-01-10 08:01:06
PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with Ki values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC50 of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively[1].

Name	PPARγ/δ modulator 1

Description	PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with Ki values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC50 of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
Target	PPARδ:14.4 nM (Ki) PPARγ:5.31 μM (Ki)
References	[1]. An S, et al. Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. Bioorg Med Chem. 2020 Jan 1;28(1):115226.

Molecular Formula	C₁₈H₁₈ClIN₆O₃Se
Molecular Weight	607.69