1430095-86-5

1430095-86-5 structure

1430095-86-5 structure

Name: JAK3-IN-12
Chemical Name: JAK3-IN-12
CAS Number: 1430095-86-5
Molecular Formula: C₁₉H₁₉N₅O₄S
Molecular Weight: 413.45
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2022-08-11 19:49:19
Modify Date: 2024-01-16 22:16:11
JAK3-IN-12 (compound 15k) is a highly potent JAK3 inhibitor with an IC50 value of 9.5 nM. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

Name	JAK3-IN-12

Description	JAK3-IN-12 (compound 15k) is a highly potent JAK3 inhibitor with an IC50 value of 9.5 nM. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK3:9.5 nM (IC50)
In Vivo	Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1]. IV (1 mg/kg); PO (3 mg/kg) Tmax (h) 0.5 Cmax (ng/ml) 146±48 tmax (h) 1.85±0.43 CL (mL/min/kg), iv 40.37 ± 3.61 AUC0-α (μg/mL·h) 192 ± 56 F (%) 15
References	[1]. Bahekar R, et al. Discovery of diaminopyrimidine-carboxamide derivatives as JAK3 inhibitors. Bioorg Chem. 2020 Jun;99:103851.

Molecular Formula	C₁₉H₁₉N₅O₄S
Molecular Weight	413.45