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2259732-60-8

2259732-60-8 structure

2259732-60-8 structure

Name: Antibacterial agent 115
Chemical Name: Antibacterial agent 115
CAS Number: 2259732-60-8
Molecular Formula: C₃₅H₄₈N₂O₃
Molecular Weight: 544.77
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-08-18 15:46:02
Modify Date: 2024-01-17 23:31:30
Antibacterial agent 115 (Compound 10) is an orally active antibacterial and anti-inflammatory agent[1].

Name	Antibacterial agent 115

Description	Antibacterial agent 115 (Compound 10) is an orally active antibacterial and anti-inflammatory agent[1].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Antibacterial agent 115 (Compound 10) shows antibacterial activity with MIC values of both 2.72 μg/mL against Staphylococcus aureussubsp.aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228) and Staphylococcus aureus (ATCC 6538)[1].
In Vivo	Antibacterial agent 115 (Compound 10) (0-40 mg/kg; i.g.; seven consecutive days) shows anti-inflammatory activity[1]. Animal Model: Kunming female mice (body weight 18–22 g), 12-O-tetradecylphorbol-13- acetate (TPA) induced ear edema mice model[1]. Dosage: 10, 20, 40 mg/kg Administration: Gavage, seven consecutive days Result: Inhibited swelling of mouse ears and inhibited the expression of TNF-α, IL-1β and p65.
References	[1]. Yang Y, et al. Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives. Bioorg Chem. 2020 Aug;101:103985.

Molecular Formula	C₃₅H₄₈N₂O₃
Molecular Weight	544.77

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