2438124-79-7

2438124-79-7 structure

Name: ALV1
Chemical Name: ALV1
CAS Number: 2438124-79-7
Molecular Formula: C₂₅H₂₃ClN₄O₅
Molecular Weight: 494.93
Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
Create Date: 2022-08-15 17:20:13
Modify Date: 2024-04-10 01:40:24
ALV1 is a potent Ikaros and Helios degrader. ALV1 potently reduces the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4. ALV1 shows similar degradation activity towards IKZF1/2/3. ALV1 induced Helios/CRBN dimerization. ALV1 promoted IL-2 secretion to a great extent[1].

Name	ALV1

Description	ALV1 is a potent Ikaros and Helios degrader. ALV1 potently reduces the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4. ALV1 shows similar degradation activity towards IKZF1/2/3. ALV1 induced Helios/CRBN dimerization. ALV1 promoted IL-2 secretion to a great extent[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	CK1α
References	[1]. Wang ES, et al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.

Molecular Formula	C₂₅H₂₃ClN₄O₅
Molecular Weight	494.93