2413656-04-7

2413656-04-7 structure

2413656-04-7 structure

Name: AChE-IN-21
Chemical Name: AChE-IN-21
CAS Number: 2413656-04-7
Molecular Formula: C₂₄H₂₉NO₄
Molecular Weight: 395.49
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-08-17 12:07:40
Modify Date: 2024-01-20 17:24:45
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1].

Name	AChE-IN-21

Description	AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	EeAChE:2.66 nM (IC50) RatBuChE:19.10 μM (IC50)
In Vitro	AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE[1].
In Vivo	AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice[1]. Animal Model: Kunming mice at body weight of 18–22 g (male and female in half)[1] Dosage: 1.0, 5.0 and 25.0 mg/kg Administration: Intragastric administration, once a day for 7 consecutive days Result: Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.
References	[1]. Luo L, et al. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 15;28(8):115400.

Molecular Formula	C₂₄H₂₉NO₄
Molecular Weight	395.49