2204280-42-0
2204280-42-0 structure
- Name: MY33-3 (hydrochloride)
- Chemical Name: MY33-3 (hydrochloride)
- CAS Number: 2204280-42-0
- Molecular Formula: C16H14ClF6NS2
- Molecular Weight: 433.86
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2022-08-27 21:47:49
- Modify Date: 2024-01-16 09:12:29
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MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].
| Name | MY33-3 (hydrochloride) |
|---|
| Description | MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | MY33-3 hydrochloride (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells[1]. MY33-3 hydrochloride (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells[2]. |
| In Vivo | MY33-3 hydrochloride (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 hydrochloride reduces preference for the ethanol solution on day 3[1]. MY33-3 hydrochloride (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability[3]. |
| References |
| Molecular Formula | C16H14ClF6NS2 |
|---|---|
| Molecular Weight | 433.86 |
| Storage condition | 2-8°C |