2490589-12-1

2490589-12-1 structure

Name: sEH/AChE-IN-4
Chemical Name: sEH/AChE-IN-4
CAS Number: 2490589-12-1
Molecular Formula: C₃₅H₃₉ClF₃N₅O₃
Molecular Weight: 670.16
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2022-07-01 22:23:52
Modify Date: 2024-01-12 14:18:25
sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].

Name	sEH/AChE-IN-4

Description	sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 3.1 nM (hsEH), 1660 ± 450 nM (hAChE), 179 ± 26 nM (hBChE), 14.5 nM (msEH), 102 ± 18 nM (mAChE)[1]
References	[1]. Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.

Molecular Formula	C₃₅H₃₉ClF₃N₅O₃
Molecular Weight	670.16