2230873-96-6
2230873-96-6 structure
- Name: KRAS inhibitor-13
- Chemical Name: KRAS inhibitor-13
- CAS Number: 2230873-96-6
- Molecular Formula: C25H19ClFN3O2S
- Molecular Weight: 479.95
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-07-02 16:44:46
- Modify Date: 2024-01-11 16:22:58
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KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
| Name | KRAS inhibitor-13 |
|---|
| Description | KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:0.883 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C25H19ClFN3O2S |
|---|---|
| Molecular Weight | 479.95 |