2376841-54-0

2376841-54-0 structure

Name: GABAA receptor agent 8
Chemical Name: GABAA receptor agent 8
CAS Number: 2376841-54-0
Molecular Formula: C₁₉H₁₆N₄O
Molecular Weight: 316.36
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2022-06-25 22:33:38
Modify Date: 2024-01-06 21:15:55
GABAA receptor agent 8 (compoud 5e) is a potent GABAA receptor positive modulator. GABAA receptor agent 8 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 8 has the potential for the research of epilepsy[1].

Name	GABAA receptor agent 8

Description	GABAA receptor agent 8 (compoud 5e) is a potent GABAA receptor positive modulator. GABAA receptor agent 8 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 8 has the potential for the research of epilepsy[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GABAA receptor[1]
In Vitro	GABAA receptor agent 8 (compoud 5e) shows anticonvulsant activity with an IC50 of 0.334 µM in 4-AP induced hyper-excitability Model[1]. GABAA receptor agent 8 (0.01-100 µM; 0-140 s) increases GABA-induced activation of GABAA1 receptor in a dose-dependent manner with EC50 12.02 µM.
In Vivo	GABAA receptor agent 8 (compoud 5e) shows anticonvulsant activity in mice with an ED50 of 40.95 mg/kg and an TD50 of 372.39 mg/kg[1]. GABAA receptor agent 8 specifically attenuates PTZ-induced seizures but not MES-induced seizures in mice[1].
References	[1]. Huang L, et al. Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity. Eur J Med Chem. 2020 Jan 1;185:111824.

Molecular Formula	C₁₉H₁₆N₄O
Molecular Weight	316.36