426224-45-5
426224-45-5 structure
- Name: ACAi-028
- Chemical Name: ACAi-028
- CAS Number: 426224-45-5
- Molecular Formula: C13H9BrN4O3S
- Molecular Weight: 381.204
- Create Date: 2022-07-01 18:04:17
- Modify Date: 2023-01-15 19:21:46
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ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD).ACAi-028 binds directly and noncovalently to HIV-1 capsid monomer.ACAi-028 inhibits the early stage of the HIV-1 life cycle and does not affect the late stage, also prevents multiple-round HIV-1 infection using HIV-1 strains (HIV-1NL4-3 and HIV-1LAI), except for HIV-2 strain (HIV-2ROD).ACAi-028 inhibits the replication of various types of HIV-1 strains (HIV-1104pre and HIV-1MDR/B) in PBMCs and HIV-1ATVR5μM in MT-4 cells, with negligible cytotoxicity.
| Name | ACAi-028 |
|---|
| Description | ACAi-028 is a small molecule inhibiting HIV-1 replication (EC50=0.55 uM) that targets a hydrophobic pocket in the N-terminal domain of capsid (CA-NTD).ACAi-028 binds directly and noncovalently to HIV-1 capsid monomer.ACAi-028 inhibits the early stage of the HIV-1 life cycle and does not affect the late stage, also prevents multiple-round HIV-1 infection using HIV-1 strains (HIV-1NL4-3 and HIV-1LAI), except for HIV-2 strain (HIV-2ROD).ACAi-028 inhibits the replication of various types of HIV-1 strains (HIV-1104pre and HIV-1MDR/B) in PBMCs and HIV-1ATVR5μM in MT-4 cells, with negligible cytotoxicity. |
|---|---|
| References | 1. Chia T, et al. Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0103921. |
| Molecular Formula | C13H9BrN4O3S |
|---|---|
| Molecular Weight | 381.204 |