431068-08-5
431068-08-5 structure
- Name: CRL inhibitor 33-11
- Chemical Name: CRL inhibitor 33-11
- CAS Number: 431068-08-5
- Molecular Formula: C19H11F3N2O4
- Molecular Weight: 388.302
- Create Date: 2022-07-11 13:43:52
- Modify Date: 2024-01-06 09:54:46
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CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro.
| Name | CRL inhibitor 33-11 |
|---|
| Description | CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro. |
|---|---|
| References | 1. Kenneth Wu, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2007328118. |
| Molecular Formula | C19H11F3N2O4 |
|---|---|
| Molecular Weight | 388.302 |