CRL inhibitor 33-11
Modify Date: 2024-01-06 09:54:46
CRL inhibitor 33-11 structure
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Common Name | CRL inhibitor 33-11 | ||
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| CAS Number | 431068-08-5 | Molecular Weight | 388.302 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H11F3N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CRL inhibitor 33-11CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro. |
| Name | CRL inhibitor 33-11 |
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| Description | CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro. |
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| References | 1. Kenneth Wu, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2007328118. |
| Molecular Formula | C19H11F3N2O4 |
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| Molecular Weight | 388.302 |