CRL inhibitor 33-11

Modify Date: 2025-08-25 19:02:15

CRL inhibitor 33-11 Structure
CRL inhibitor 33-11 structure
 Common Name CRL inhibitor 33-11
CAS Number 431068-08-5 Molecular Weight 388.302
Density N/A Boiling Point N/A
Molecular Formula C19H11F3N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CRL inhibitor 33-11


CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro.

 Names

Name CRL inhibitor 33-11

 CRL inhibitor 33-11 Biological Activity

Description CRL inhibitor 33-11 is a small moelcule E3 CRL inhibitor, directly and selectively binds to the purified E3 ROC1-CUL4A CTD and ROC1-CUL1 CTD complex with Kd of 0.223 and 4.53 uM, respecitvely.CRL inhibitor 33-11 binds to ROC1-CUL1 more effectively than ROC1-CUL1-Nedd8.CRL inhibitor 33-11 showed the ability to inhibit ubiquitination by ROC1–CUL1 more potently than that by ROC1-CUL1-Nedd8.CRL inhibitor 33-11 inhibited the ubiquitination of CK1α by CRL4CRBN in vitro.
References 1. Kenneth Wu, et al. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2007328118.

 Chemical & Physical Properties

Molecular Formula C19H11F3N2O4
Molecular Weight 388.302
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