2704564-03-2
2704564-03-2 structure
- Name: G2019S-LRRK2 inhibitor 38
- Chemical Name: G2019S-LRRK2 inhibitor 38
- CAS Number: 2704564-03-2
- Molecular Formula: C24H21N5
- Molecular Weight: 379.467
- Create Date: 2022-07-02 20:28:36
- Modify Date: 2024-01-20 16:42:42
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G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice.
| Name | G2019S-LRRK2 inhibitor 38 |
|---|
| Description | G2019S-LRRK2 inhibitor 38 is a potent, selective, brain penetrant G2019S-LRRK2 kinase inhibitor with IC50 of <1 nM, cellular EC50 of 40 nM, >2,000-fold selectivity over WT LRRK2 (cellular EC50>100 uM).G2019S-LRRK2 inhibitor 38 selectively inhibit phosphorylation of Ser935 in vitro, and in brain, lung, kidney and spleen in G2019S-LRRK2 mice. |
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| References | 1. Robert K Leśniak, et al. Eur J Med Chem. 2022 Feb 5;229:114080. |
| Molecular Formula | C24H21N5 |
|---|---|
| Molecular Weight | 379.467 |