259089-67-3
259089-67-3 structure
- Name: SEW84
- Chemical Name: SEW84
- CAS Number: 259089-67-3
- Molecular Formula: C19H14F4N4Os
- Molecular Weight: 422.402
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
- Create Date: 2022-07-01 18:27:31
- Modify Date: 2025-08-13 00:54:14
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SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase;SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy.
| Name | SEW84 |
|---|
| Description | SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase;SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy. |
|---|---|
| References | 1. Jay K Singh, et al. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6. |
| Molecular Formula | C19H14F4N4Os |
|---|---|
| Molecular Weight | 422.402 |