2566480-63-3
2566480-63-3 structure
- Name: UC-764865
- Chemical Name: UC-764865
- CAS Number: 2566480-63-3
- Molecular Formula: C18H16N2O2S
- Molecular Weight: 324.398
- Create Date: 2022-07-02 10:53:38
- Modify Date: 2024-04-03 10:48:58
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UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro.
| Name | UC-764865 |
|---|
| Description | UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro. |
|---|---|
| References | 1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695. |
| Molecular Formula | C18H16N2O2S |
|---|---|
| Molecular Weight | 324.398 |