116679-69-7
116679-69-7 structure
- Name: UC-773587
- Chemical Name: UC-773587
- CAS Number: 116679-69-7
- Molecular Formula: C28H16O5
- Molecular Weight: 432.431
- Create Date: 2020-01-19 22:38:57
- Modify Date: 2022-08-14 12:38:27
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A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells.
| Name | UC-773587 |
|---|
| Description | A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells. |
|---|---|
| References | References 1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98. View Related Products by Target Ras |
| Molecular Formula | C28H16O5 |
|---|---|
| Molecular Weight | 432.431 |