2375554-02-0
2375554-02-0 structure
- Name: Senexin C
- Chemical Name: Senexin C
- CAS Number: 2375554-02-0
- Molecular Formula: C28H27N5O
- Molecular Weight: 449.558
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2022-08-17 18:24:18
- Modify Date: 2024-01-19 14:06:23
-
Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability.
| Name | Senexin C |
|---|
| Description | Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability. |
|---|---|
| References | 1. Li Zhang, et al. J. Med. Chem. 2022 |
| Molecular Formula | C28H27N5O |
|---|---|
| Molecular Weight | 449.558 |