Senexin C
Modify Date: 2024-01-19 14:06:23
Senexin C structure
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Common Name | Senexin C | ||
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| CAS Number | 2375554-02-0 | Molecular Weight | 449.558 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H27N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Senexin CSenexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability. |
| Name | Senexin C |
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| Description | Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability. |
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| References | 1. Li Zhang, et al. J. Med. Chem. 2022 |
| Molecular Formula | C28H27N5O |
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| Molecular Weight | 449.558 |