2116590-65-7
2116590-65-7 structure
- Name: UAMC-2526
- Chemical Name: UAMC-2526
- CAS Number: 2116590-65-7
- Molecular Formula: C16H15BrO6
- Molecular Weight: 383.194
- Create Date: 2022-07-02 16:06:45
- Modify Date: 2024-01-07 00:19:04
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UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.UAMC-2526 (50-100 uM) completely inhibits proliferation of HT-29 colorectal carcinoma cells.UMAC-2526 inhibits autophagy in a colorectal cancer xenograft model and potentiates chemotherapy efficacy.UMAC-256 inhibits autophagy in a healthy mouse model, animals treated withcompound UAMC-2526 showed lower levels of uncleaved (free) GFP, decreased LC3-II/LC3-I ratios and a marked increase of SQSTM1.UAMC-2526 combined with gemcitabine significantly reduced tumor growth as compared to the individual treatments, did not inhibit autophagy in the Panc02 mouse model.
| Name | UAMC-2526 |
|---|
| Description | UAMC-2526 (UAMC2526) is a low micromolar ATG4B and autophagy inhibitor.UAMC-2526 (50-100 uM) completely inhibits proliferation of HT-29 colorectal carcinoma cells.UMAC-2526 inhibits autophagy in a colorectal cancer xenograft model and potentiates chemotherapy efficacy.UMAC-256 inhibits autophagy in a healthy mouse model, animals treated withcompound UAMC-2526 showed lower levels of uncleaved (free) GFP, decreased LC3-II/LC3-I ratios and a marked increase of SQSTM1.UAMC-2526 combined with gemcitabine significantly reduced tumor growth as compared to the individual treatments, did not inhibit autophagy in the Panc02 mouse model. |
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| References | 1. Kurdi A, et al. Biochem Pharmacol. 2017 Aug 15;138:150-162. 2. Salado IG, et al. Eur J Med Chem. 2018 May 10;151:18-26. 3. Takhsha FS, et al. Front Oncol. 2021 Nov 18;11:750259. |
| Molecular Formula | C16H15BrO6 |
|---|---|
| Molecular Weight | 383.194 |