Name | buclizine |
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Synonyms |
Buclozin
1-<4-Chlor-benzhydryl>-4-<4-tert.-butyl-benzyl>-piperazin Histabuticine BUCLIZINE AH 2526 Buclifen aphilan-rbase Postafen Bucladin Hitabutyzyne |
Description | Buclizine is an orally active antihistamine antiallergic compound. Buclizine is a potent teratogen in the rat and shows anti-tumor activity[1][2][3]. |
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Related Catalog | |
In Vitro | Buclizine (0.1-100 μM; 72 h) inhibits growth of MCF-7 cells[2]. Buclizine (9.625-77 μM; 72 h) arrests the cell cycle in the G1 phase in a dose-dependent manner[2]. Buclizine (0-75 μM; 72 h) decreases TCTP (translationally controlled tumor protein) and cell cycle regulatory proteins expression in MCF-7 cells, increases pro-apoptotic MCL-1S expression[2]. Cell Proliferation Assay[2] Cell Line: MCF-7 cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed considerable growth inhibition (IC50=19.18 μM). Cell Cycle Analysis[2] Cell Line: MCF-7 cells Concentration: 9.625, 19.25, 38.5, and 77 μM Incubation Time: 72 hours Result: Increased the percentages of cells in the G1 phase to 73% at 77 μM. Western Blot Analysis[2] Cell Line: MCF-7 cells Concentration: 0-75 μM Incubation Time: 72 hours Result: Decreased TCTP expression by 40% at 75 μM. Decreased cyclin D1, cyclin D3, CDK2 and CDK4 expression after 72 h. |
In Vivo | Buclizine dihydrochloride (30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation) shows potent teratogens in the rat[3]. Animal Model: Eighty-seven mature female rats weighing 240±20 grams[3] Dosage: 30, 40, 60, 100, and 200 mg/kg Administration: 30-200 mg/kg; tenth to fifteenth and twelfth to fifteenth days of gestation Result: Resulted in malformations in 100% of the young at a dose level of 60-100 mg/kg. |
References |
[1]. Gamal A E Mostafa, et al. Buclizine. Profiles Drug Subst Excip Relat Methodol. 2011;36:1-33. |
Molecular Formula | C28H33ClN2 |
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Molecular Weight | 433.02800 |
Exact Mass | 432.23300 |
PSA | 6.48000 |
LogP | 6.42050 |
Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xi |
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HS Code | 2933599090 |
HS Code | 2933599090 |
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Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |