1627694-81-8
1627694-81-8 structure
- Name: PBI-4547
- Chemical Name: PBI-4547
- CAS Number: 1627694-81-8
- Molecular Formula: C18H27NaO2
- Molecular Weight: 298.402
- Create Date: 2022-07-17 10:43:35
- Modify Date: 2024-01-11 21:00:48
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PBI-4547 is an agonist of GPR40/120 and an antagonist of GPR84, also is a partial ligand and activator of PPAR.PBI-4547 dose-dependently inhibits GPR84/Gαi2 activation (reflected by an increase in BRET signal) with IC50 of 17 uM, activates GPR40 (EC50 of 102 µM for Gαq and 16 µM for Gαi2) and dose-dependently promoted β-arrestin-2 recruitment to GPR120 (EC50=148 uM).PBI-4547 prevents progression, improves glucose metabolism in a mouse model of NAFLD, restores hepatic glucose and FA metabolism.
| Name | PBI-4547 |
|---|
| Description | PBI-4547 is an agonist of GPR40/120 and an antagonist of GPR84, also is a partial ligand and activator of PPAR.PBI-4547 dose-dependently inhibits GPR84/Gαi2 activation (reflected by an increase in BRET signal) with IC50 of 17 uM, activates GPR40 (EC50 of 102 µM for Gαq and 16 µM for Gαi2) and dose-dependently promoted β-arrestin-2 recruitment to GPR120 (EC50=148 uM).PBI-4547 prevents progression, improves glucose metabolism in a mouse model of NAFLD, restores hepatic glucose and FA metabolism. |
|---|---|
| References | 1. Simard JC, et al. Sci Rep. 2020 Jul 29;10(1):12778. |
| Molecular Formula | C18H27NaO2 |
|---|---|
| Molecular Weight | 298.402 |