2459932-81-9
2459932-81-9 structure
- Name: EGFR-IN-49
- Chemical Name: EGFR-IN-49
- CAS Number: 2459932-81-9
- Molecular Formula: C22H15N5O2S
- Molecular Weight: 413.45
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2022-07-19 22:15:43
- Modify Date: 2024-01-11 14:04:51
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EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner[1].
| Name | EGFR-IN-49 |
|---|
| Description | EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner[1]. |
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| Related Catalog | |
| Target |
EGFRT790M:65.0 nM (IC50) EGFRL858R/T790M:13.6 nM (IC50) |
| In Vitro | EGFR-IN-49 (compound 13a) (1, 10 µM) shows inhibition activity for H1975 cells with an IC50 of 699.2 nM[1]. EGFR-IN-49 (1 µM) shows an strong inhibitory activity to EGFRT790M, EGFRT790M/L858R, EGFRWT with IC50s of 65.0, 13.6, >1000 nM, respectively[1]. EGFR-IN-49 (0.2, 4, 8 µM; 48 h) induces cell apoptosis in a dose-dependent manner in A431 cells[1]. Cell Proliferation Assay[1] Cell Line: A549, A431, Hela, MCF7, LO2 cells Concentration: 0-50 µM Incubation Time: Result: Showed excellent anti-proliferative activities with IC50s of 4.34, 3.79, 6.39, 18.99, >50 µM for A549, A431, Hela, MCF7, LO2 cells, respectively. Apoptosis Analysis[1] Cell Line: A431 cells Concentration: 0.2, 4, 8 µM Incubation Time: 48 h Result: Induced cell apoptosis in a low concentration (0.33 µM) and exhibited higher percent of 16.41% % in the stage of late apoptotic at concentration of 4 µM. |
| References |
| Molecular Formula | C22H15N5O2S |
|---|---|
| Molecular Weight | 413.45 |