2376333-77-4

2376333-77-4 structure

Name: Dopamine D3 receptor ligand-4
Chemical Name: Dopamine D3 receptor ligand-4
CAS Number: 2376333-77-4
Molecular Formula: C₂₆H₂₈N₄OS
Molecular Weight: 444.59
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2022-06-29 22:09:39
Modify Date: 2024-04-05 20:21:30
Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D3 receptor ligand, with a Ki of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D3 over D2 (Ki=7.43 nM). Dopamine D3 receptor ligand-4 can be used for the research of Cocaine use disorder[1].

Name	Dopamine D3 receptor ligand-4

Description	Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D3 receptor ligand, with a Ki of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D3 over D2 (Ki=7.43 nM). Dopamine D3 receptor ligand-4 can be used for the research of Cocaine use disorder[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D3 Receptor:0.5 nM (Ki) D2 Receptor:7.43 nM (Ki)
References	[1]. Blass BE, et al. Design, synthesis, and evaluation of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides as selective dopamine D3 receptor ligands. Med Chem Res 31, 132-145 (2022).

Molecular Formula	C₂₆H₂₈N₄OS
Molecular Weight	444.59