1644626-43-6

1644626-43-6 structure

Name: TDRL-551
Chemical Name: TDRL-551
CAS Number: 1644626-43-6
Molecular Formula: C₂₅H₂₃ClIN₃O₄
Molecular Weight: 591.83
Create Date: 2022-05-21 15:27:27
Modify Date: 2025-09-18 16:52:49
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].

Name	TDRL-551

Description	TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33.

Molecular Formula	C₂₅H₂₃ClIN₃O₄
Molecular Weight	591.83