TDRL-551
Modify Date: 2024-01-21 16:22:49
TDRL-551 structure
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Common Name | TDRL-551 | ||
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| CAS Number | 1644626-43-6 | Molecular Weight | 591.83 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H23ClIN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TDRL-551TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1]. |
| Name | TDRL-551 |
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| Description | TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1]. |
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| References |
| Molecular Formula | C25H23ClIN3O4 |
|---|---|
| Molecular Weight | 591.83 |