2413648-96-9

2413648-96-9 structure

Name: EV-A71-IN-1
Chemical Name: EV-A71-IN-1
CAS Number: 2413648-96-9
Molecular Formula: C₂₁H₁₅N₅S
Molecular Weight: 369.44
Create Date: 2022-05-16 19:17:41
Modify Date: 2025-09-18 20:21:37
EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM)[1].

Name	EV-A71-IN-1

Description	EV-A71-IN-1 is a human enterovirus A71 (EV-A71) capsid protein inhibitor with an EC50 of 0.27 μM against EV-A71. EV-A71-IN-1 is a capsid binder that blocks the interaction between the viral VP1 and the host receptor hSCARB2. EV-A71-IN-1 inhibits a series of different human enteroviruses without significant cytotoxicity (CC50>56.2 μM)[1].
Related Catalog	Research Areas >> Infection
In Vitro	EV-A71-IN-1 (compound 12s) shows activity not only against different EV-A71 strains (BrCr, GZ-CII, EV71/HeN09 and EV71/G082) but also against other representative enteroviruses (CV-A16, EV-D68, Echov-6, CV-B2 and CV-B6)[1].
References	[1]. Xu Z, et al. Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors. Bioorg Chem. 2022;122:105683.

Molecular Formula	C₂₁H₁₅N₅S
Molecular Weight	369.44