2711105-54-1
2711105-54-1 structure
- Name: EGFR-IN-36
- Chemical Name: EGFR-IN-36
- CAS Number: 2711105-54-1
- Molecular Formula: C26H25ClN6O2
- Molecular Weight: 488.97
- Create Date: 2022-05-13 18:11:02
- Modify Date: 2025-08-25 11:29:11
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EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].
| Name | EGFR-IN-36 |
|---|
| Description | EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1]. |
|---|---|
| Related Catalog | |
| Target |
EGFR (WT):19.09 nM (IC50) HER2(WT):120.01 nM (IC50) HER2 (A775_G776insYVMA):2.35 nM (IC50) |
| In Vitro | EGFR-IN-36 (compound 8) inhibits A431 cell (IC50=223.6 nM),A549 cell (IC50=7644.42 nM), H1975 cell (IC50=20.68 nM)[1]. |
| References |
| Molecular Formula | C26H25ClN6O2 |
|---|---|
| Molecular Weight | 488.97 |