885496-53-7

885496-53-7 structure

Name: S-777469
Chemical Name: S-777469
CAS Number: 885496-53-7
Molecular Formula: C₂₃H₂₇FN₂O₄
Molecular Weight: 414.47
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2022-04-07 06:08:15
Modify Date: 2024-01-10 09:37:17
S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism[1][2].

Name	S-777469

Description	S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
References	[1]. Odan M, et al. Discovery of S-777469: an orally available CB2 agonist as an antipruritic agent. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2803-6. [2]. Haruna T, et al. S-777469, a novel cannabinoid type 2 receptor agonist, suppresses itch-associated scratching behavior in rodents through inhibition of itch signal transmission. Pharmacology. 2015;95(1-2):95-103.

Molecular Formula	C₂₃H₂₇FN₂O₄
Molecular Weight	414.47