2615910-00-2

2615910-00-2 structure

Name: CCG258747
Chemical Name: CCG258747
CAS Number: 2615910-00-2
Molecular Formula: C₂₈H₂₇FN₄O₄
Molecular Weight: 502.54
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2022-04-29 17:58:48
Modify Date: 2024-01-10 13:44:35
CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure[1].

Name	CCG258747

Description	CCG258747 is a selective GRK2 inhibitor (IC50=18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, >5500, and >550–fold, respectively).CCG258747 also blocks the internalization of the µ-opioid receptor. G protein-coupled receptor (GPCR) kinases (GRKs) are attractive targets for the research of heart failure[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
References	[1]. Renee A Bouley, et al. A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor. Mol Pharmacol. 2020 Jun;97(6):392-401.

Molecular Formula	C₂₈H₂₇FN₄O₄
Molecular Weight	502.54