1416313-72-8

1416313-72-8 structure

Name: Dynole 2−24
Chemical Name: Dynole 2−24
CAS Number: 1416313-72-8
Molecular Formula: C₂₄H₄₁N₃
Molecular Weight: 371.60
Catalog: Signaling Pathways Cytoskeleton Dynamin
Create Date: 2022-03-23 15:40:24
Modify Date: 2025-08-25 18:00:02
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis

Name	Dynole 2−24

Description	Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Cytoskeleton >> Dynamin
References	[1]. Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59.

Molecular Formula	C₂₄H₄₁N₃
Molecular Weight	371.60

Hazard Codes	Xi