DC Chemicals Limited
China
Product Name: CTB
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Purity: 98.0%
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Contact: Tony Cao

451491-47-7

451491-47-7 structure

451491-47-7 structure

Name: CTB
Chemical Name: CTB
CAS Number: 451491-47-7
Molecular Formula: C₁₆H₁₃ClF₃NO₂
Molecular Weight: 343.73
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-02-25 17:22:14
Modify Date: 2024-01-06 10:25:02
CTB (Cholera Toxin B subunit) is a potent p300 histone acetyltransferase activator[1]. CTB can effectively induce apoptosis in MCF-7 cells[2].

Name	CTB
Synonyms	MFCD02356522

Description	CTB (Cholera Toxin B subunit) is a potent p300 histone acetyltransferase activator[1]. CTB can effectively induce apoptosis in MCF-7 cells[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Research Areas >> Neurological Disease
Target	p300
In Vitro	CTB (10, 50, 100, 150, 200, and 250 µM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner[1]. CTB (0-200 μM; 24 hours) inhibits the viability of MCF-7 cells with an IC50 of 85.43 μM[2]. CTB (85.43 μM; 24, 48 and 72 h) induces time dependence apoptosis of MCF-7 cells[2]. CTB (50 uM; 24 h) increases p300/CBP activity , and reduces autophagic flux in primary neurons[3]. Cell Viability Assay[2] Cell Line: MCF-7 cell Concentration: 0-200 μM Incubation Time: 24 hours Result: Inhibit viability with an IC50 of 85.43 μM. Apoptosis Analysis[2] Cell Line: MCF-7 cell Concentration: 85.43 μM Incubation Time: 24, 48 and 72 h Result: Iinduced time-dependence apoptosis.
References	[1]. Mantelingu K, et al. Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy. J Phys Chem B. 2007;111(17):4527-4534. [2]. Dastjerdi MN, et al. The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines. Adv Biomed Res. 2013;2:24. Published 2013 Mar 6. [3]. Chen X, et al. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Mol Neurodegener. 2020;15(1):2. Published 2020 Jan 6.

Molecular Formula	C₁₆H₁₃ClF₃NO₂
Molecular Weight	343.73

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H319-H410
Precautionary Statements	P273-P305 + P351 + P338-P501
Hazard Codes	Xi
RIDADR	UN 3077 9 / PGIII