674359-73-0
674359-73-0 structure
- Name: Rasarfin
- Chemical Name: Rasarfin
- CAS Number: 674359-73-0
- Molecular Formula: C23H24ClN3O3
- Molecular Weight: 425.91
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2022-02-26 05:57:49
- Modify Date: 2024-04-06 11:49:31
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Rasarfin is a dual Ras and ARF6 inhibitor[1].
| Name | Rasarfin |
|---|
| Description | Rasarfin is a dual Ras and ARF6 inhibitor[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Rasarfin also potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation[1]. Rasarfin blocks GPCR internalization through inhibition of ARF6[1]. Rasarfin treatment results in a dose-dependent reduction in MDA-MB-231 cells[1]. Rasarfin inhibits the recruitment of the clathrin adaptor AP-2 to β-arrestin2 and receptor internalization, both processes that require active ARF6[1]. |
| References |
| Molecular Formula | C23H24ClN3O3 |
|---|---|
| Molecular Weight | 425.91 |
| Hazard Codes | Xi |
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